HIV Target gene Detail Information

> NNT Gene Search Result

Gene Information

Gene Name	NNT
Gene ID	23530
Gene Full Name	nicotinamide nucleotide transhydrogenase
Gene Alias	GCCD4
Transcripts	ENSG00000112992
Virus	HIV
Gene Type	protein coding
HPA Location Info	Mitochondria;Cytosol;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q13423
HGNC ID	HGNC:7863
VEGA ID	OTTHUMG00000096961
OMIM ID	607878
String ID	9606.ENSP00000264663
Drugbank ID	BE0000008
PharmGKB ID	PA31667

Target gene [NNT] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4006799	chr5	19	3		22	View
4013374	chr5		3		3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of NNT expression and immune infiltrating cell level correlation result in HIV+ samples
NNT expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of NNT expression and immune infiltrating cell level correlation result in HIV+ samples
NNT expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).