HPV Target gene Detail Information

> NKX3-2 Gene Search Result

Gene Information

Gene Name	NKX3-2
Gene ID	579
Gene Full Name	NK3 homeobox 2
Gene Alias	SMMD; BAPX1; NKX3B; NKX3.2
Transcripts	ENSG00000109705
Virus	HPV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins, Transcription factors
Uniport_ID	P78367
HGNC ID	HGNC:951
VEGA ID	OTTHUMG00000090657
OMIM ID	602183
String ID	9606.ENSP00000371875
PharmGKB ID	PA162397617

Target gene [NKX3-2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5403761	chr4	39	1	4	44	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE140662 (GEO)	Condyloma Acuminatum	8	Condyloma acuminata (HPV+)(5), Skin(3)
GSE55546 (GEO)	Oropharyngeal squamous cell carcinoma	16	Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO)	Oropharyngeal squamous cell carcinoma	23	Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO)	Oropharyngeal squamous cell carcinoma	36	Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662
HeatMap of cell type fractions in all samples	Lollipop of NKX3-2 expression and immune infiltrating cell level correlation result in HPV+ samples
NKX3-2 expression: Low -> High

> Dataset: GSE55546
HeatMap of cell type fractions in all samples	Lollipop of NKX3-2 expression and immune infiltrating cell level correlation result in HPV+ samples
NKX3-2 expression: Low -> High

> Dataset: GSE55544
HeatMap of cell type fractions in all samples	Lollipop of NKX3-2 expression and immune infiltrating cell level correlation result in HPV+ samples
NKX3-2 expression: Low -> High

> Dataset: GSE55542
HeatMap of cell type fractions in all samples	Lollipop of NKX3-2 expression and immune infiltrating cell level correlation result in HPV+ samples
NKX3-2 expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of NKX3-2 expression and immune infiltrating cell level correlation result in HPV+ samples
NKX3-2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE140662