HTLV1 Target gene Detail Information

> NHLRC1 Gene Search Result

Gene Information

Gene Name	NHLRC1
Gene ID	378884
Gene Full Name	NHL repeat containing E3 ubiquitin protein ligase 1
Gene Alias	EPM2A; EPM2B; MALIN; bA204B7.2
Transcripts	ENSG00000187566
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Vesicles;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q6VVB1
HGNC ID	HGNC:21576
VEGA ID	OTTHUMG00000014315
OMIM ID	608072
String ID	9606.ENSP00000345464
PharmGKB ID	PA134916338

Target gene [NHLRC1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6000195	chr6	2519	395	224	3138	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of NHLRC1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
NHLRC1 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of NHLRC1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
NHLRC1 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of NHLRC1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
NHLRC1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).