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EBV Target gene Detail Information

> NFKB1 Gene Search Result


Gene Information
Gene Name NFKB1
Gene ID 4790
Gene Full Name nuclear factor kappa B subunit 1
Gene Alias p50; KBF1; p105; EBP-1; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B1
Transcripts ENSG00000109320
Virus EBV
Gene Type protein coding
HPA Location Info Nucleoplasm;Cytosol;
HPA Protein Class Info Cancer-related genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins, Transcription factors
Gene Function Suppressor gene
Uniport_ID P19838
HGNC ID HGNC:7794
VEGA ID OTTHUMG00000161080
OMIM ID 164011
String ID 9606.ENSP00000226574
Drugbank ID BE0001086; BE0009554; BE0004903
PharmGKB ID PA248
Target gene [NFKB1] related to virus gene/protein/region
ID PMID Mutation Gene/Protein/Region Description Detail
1 22384168 D150A
LMP1
R
C
 View
2 14687985 69-bp del
LMP1
R
 View
3 14687985 333_355aa del
LMP1
R
 View
4 18986987 G212S
LMP1
R
 View
5 9733827 Q206A
LMP1
 View
6 9733827 P204A
LMP1
 View
7 21560118 D150A
LMP1
 View
8 19119421 K122A
BILF1
 View
9 25436768 351-386 del
LMP1
 View
10 9123876 L214R
BZLF1
 View
11 9123876 L214S
BZLF1
 View
12 9123876 L218R
BZLF1
 View
13 9123876 L218S
BZLF1
 View
14 9123876 I216S
BZLF1
 View
15 9123876 D225E
BZLF1
 View
16 9123876 Y200E
BZLF1
 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE102203 (GEO) B-cell lymphoma 9 Plasmablastic lymphomas (EBV+)(6), Plasmablastic lymphomas (EBV-)(3)
GSE100458 (GEO) Burkitt lymphoma 14 Burkitt lyphoma cell line Akata(EBV+)(2),Burkitt lyphoma cell line Akata(EBV-)(2),Burkitt lyphoma cell line Awia(EBV+)(2),Burkitt lyphoma cell line Awia(EBV-)(2),Burkitt lyphoma cell line Eli(EBV+)(1),Burkitt lyphoma cell line Eli(EBV-)(1),Burkitt lyphoma cell line Mutu(EBV+)(2),Burkitt lyphoma cell line Mutu(EBV-)(2)
GSE42867 (GEO) Burkitt lymphoma 12 Burkitt lymphoma cell line Awia (EBV+)(12)
GSE135644 (GEO) Gastric carcinoma 10 Gastric adenocarcinoma cell line AGS (5), Gastric adenocarcinoma cell line AGS (EBV+)(5)
GSE45919 (GEO) Infectious mononucleosis 24 Infectious mononucleosis (IM)(EBV+)(3), Normal (9), Latent EBV (12)
GSE85599 (GEO) Infectious mononucleosis 17 Chronic active EBV infection (EBV+)(5), Acute infectious mononucleosis (EBV+)(6), Normal (6)
GSE58240 (GEO) Multiple sclerosis 32 Multiple sclerosis IFN-β treated (EBV+)(16), Multiple sclerosis untreated (EBV+)(16)
GSE12452 (GEO) Nasopharyngeal carcinoma 41 Nasopharyngeal carcinoma (EBV+)(31), Normal(10)

> Dataset: GSE102203

HeatMap of cell type fractions in all samples Lollipop of NFKB1 expression and immune infiltrating cell level correlation result in EBV+ samples
NFKB1 expression: Low -> High

> Dataset: GSE100458

HeatMap of cell type fractions in all samples Lollipop of NFKB1 expression and immune infiltrating cell level correlation result in EBV+ samples
NFKB1 expression: Low -> High

> Dataset: GSE42867

HeatMap of cell type fractions in all samples Lollipop of NFKB1 expression and immune infiltrating cell level correlation result in EBV+ samples
NFKB1 expression: Low -> High

> Dataset: GSE135644

HeatMap of cell type fractions in all samples Lollipop of NFKB1 expression and immune infiltrating cell level correlation result in EBV+ samples
NFKB1 expression: Low -> High

> Dataset: GSE45919

HeatMap of cell type fractions in all samples Lollipop of NFKB1 expression and immune infiltrating cell level correlation result in EBV+ samples
NFKB1 expression: Low -> High

> Dataset: GSE85599

HeatMap of cell type fractions in all samples Lollipop of NFKB1 expression and immune infiltrating cell level correlation result in EBV+ samples
NFKB1 expression: Low -> High

> Dataset: GSE58240

HeatMap of cell type fractions in all samples Lollipop of NFKB1 expression and immune infiltrating cell level correlation result in EBV+ samples
NFKB1 expression: Low -> High

> Dataset: GSE12452

HeatMap of cell type fractions in all samples Lollipop of NFKB1 expression and immune infiltrating cell level correlation result in EBV+ samples
NFKB1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).