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HBV Target gene Detail Information

> NFE2L2 Gene Search Result


Gene Information
Gene Name NFE2L2
Gene ID 4780
Gene Full Name nuclear factor, erythroid 2 like 2
Gene Alias NRF2; HEBP1; IMDDHH
Transcripts ENSG00000116044
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoplasm;Plasma membrane;Cytosol;
HPA Protein Class Info Cancer-related genes, Predicted intracellular proteins, Transcription factors
Uniport_ID Q16236
HGNC ID HGNC:7782
VEGA ID OTTHUMG00000133620
OMIM ID 600492
String ID 9606.ENSP00000380252
PharmGKB ID PA31588
Target gene [NFE2L2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1002595 chr2 241 241 View
1002596 chr2 241 241 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of NFE2L2 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
NFE2L2 expression: Low -> High
Lollipop of NFE2L2 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of NFE2L2 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of NFE2L2 expression and immune infiltrating cell level correlation result in HBV+ samples
NFE2L2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).