HBV Target gene Detail Information

> NF1 Gene Search Result


Gene Information
Gene Name NF1
Gene ID 4763
Gene Full Name neurofibromin 1
Gene Alias WSS; NFNS; VRNF
Transcripts ENSG00000196712
Virus HBV
Gene Type protein coding
HPA Location Info Mitochondria;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins
Gene Function Suppressor gene
Uniport_ID P21359
HGNC ID HGNC:7765
VEGA ID OTTHUMG00000132871
OMIM ID 613113
String ID 9606.ENSP00000351015
PharmGKB ID PA31572
Target gene [NF1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1001007 chr17 229 465 464 1158 View
1001441 chr17 625 52 30 707 View
1006464 chr17 30 8 38 View
1009468 chr17 4 11 1 16 View
1012734 chr17 5 1 6 View
1013302 chr17 4 1 5 View
1017365 chr17 1 1 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of NF1 expression and immune infiltrating cell level correlation result in HBV+ samples
NF1 expression: Low -> High

Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).