HBV Target gene Detail Information

> NF1 Gene Search Result

Gene Information

Gene Name	NF1
Gene ID	4763
Gene Full Name	neurofibromin 1
Gene Alias	WSS; NFNS; VRNF
Transcripts	ENSG00000196712
Virus	HBV
Gene Type	protein coding
HPA Location Info	Mitochondria;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins
Gene Function	Suppressor gene
Uniport_ID	P21359
HGNC ID	HGNC:7765
VEGA ID	OTTHUMG00000132871
OMIM ID	613113
String ID	9606.ENSP00000351015
PharmGKB ID	PA31572

Target gene [NF1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1001007	chr17	229	465	464	1158	View
1001441	chr17	625	52	30	707	View
1006464	chr17	30	8		38	View
1009468	chr17	4	11	1	16	View
1012734	chr17		5	1	6	View
1013302	chr17		4	1	5	View
1017365	chr17	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of NF1 expression and immune infiltrating cell level correlation result in HBV+ samples
NF1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).