HTLV1 Target gene Detail Information

> NEK4 Gene Search Result

Gene Information

Gene Name	NEK4
Gene ID	6787
Gene Full Name	NIMA related kinase 4
Gene Alias	NRK2; STK2; pp12301
Transcripts	ENSG00000114904
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P51957
HGNC ID	HGNC:11399
VEGA ID	OTTHUMG00000158836
OMIM ID	601959
String ID	9606.ENSP00000233027
Drugbank ID	BE0009452
PharmGKB ID	PA31548

Target gene [NEK4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6004627	chr3	108	1		109	View
6012408	chr3	13	8	1	22	View
6012412	chr3	13	8	1	22	View
6013732	chr3	10	8		18	View
6014001	chr3	13	3	1	17	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of NEK4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
NEK4 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of NEK4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
NEK4 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of NEK4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
NEK4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).