HTLV1 Target gene Detail Information

> NEK10 Gene Search Result


Gene Information
Gene Name NEK10
Gene ID 152110
Gene Full Name NIMA related kinase 10
Transcripts ENSG00000163491
Virus HTLV1
Gene Type protein coding
HPA Location Info Vesicles;Nucleoplasm;
HPA Protein Class Info Enzymes, Predicted intracellular proteins
Uniport_ID Q6ZWH5
HGNC ID HGNC:18592
VEGA ID OTTHUMG00000130571
OMIM ID 618726
String ID 9606.ENSP00000343847
PharmGKB ID PA38594
Target gene [NEK10] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6026673 chr3 2 2 View
6030122 chr3 1 1 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of NEK10 expression and immune infiltrating cell level correlation result in HTLV1+ samples
NEK10 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of NEK10 expression and immune infiltrating cell level correlation result in HTLV1+ samples
NEK10 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of NEK10 expression and immune infiltrating cell level correlation result in HTLV1+ samples
NEK10 expression: Low -> High

Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).