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HBV Target gene Detail Information

> NEDD4L Gene Search Result


Gene Information
Gene Name NEDD4L
Gene ID 23327
Gene Full Name neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Gene Alias RSP5; PVNH7; NEDD4-2; NEDD4.2; hNEDD4-2
Transcripts ENSG00000049759
Virus HBV
Gene Type protein coding
HPA Location Info
HPA Protein Class Info Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Gene Function Suppressor gene
Uniport_ID Q96PU5
HGNC ID HGNC:7728
VEGA ID OTTHUMG00000179875
OMIM ID 606384
String ID 9606.ENSP00000383199
PharmGKB ID PA31534
Target gene [NEDD4L] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1002582 chr18 43 63 137 243 View
1003476 chr18 101 29 1 131 View
1008538 chr18 6 14 20 View
1010534 chr18 4 4 4 12 View
1018296 chr18 0 View
1019665 chr18 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of NEDD4L expression and immune infiltrating cell level correlation result in HBV+ samples
NEDD4L expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).