HIV Target gene Detail Information

> NCOA4 Gene Search Result

Gene Information

Gene Name	NCOA4
Gene ID	8031
Gene Full Name	nuclear receptor coactivator 4
Gene Alias	RFG; ELE1; PTC3; ARA70
Transcripts	ENSG00000266412
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoli;Cytosol;Golgi apparatus;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Predicted intracellular proteins
Gene Function	Suppressor gene & Oncogene
Uniport_ID	Q13772
HGNC ID	HGNC:7671
VEGA ID	OTTHUMG00000188314
OMIM ID	601984
String ID	9606.ENSP00000463027
PharmGKB ID	PA31473

Target gene [NCOA4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001530	chr10	88	35	31	154	View
4001837	chr10	87	29	12	128	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of NCOA4 expression and immune infiltrating cell level correlation result in HIV+ samples
NCOA4 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of NCOA4 expression and immune infiltrating cell level correlation result in HIV+ samples
NCOA4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).