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HBV Target gene Detail Information

> NCOA2 Gene Search Result


Gene Information
Gene Name NCOA2
Gene ID 10499
Gene Full Name nuclear receptor coactivator 2
Gene Alias SRC2; TIF2; GRIP1; KAT13C; NCoA-2; bHLHe75
Transcripts ENSG00000140396
Virus HBV
Gene Type protein coding
HPA Location Info Nuclear bodies;Nucleoplasm;
HPA Protein Class Info Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors
Uniport_ID Q15596
HGNC ID HGNC:7669
VEGA ID OTTHUMG00000164671
OMIM ID 601993
String ID 9606.ENSP00000399968
Drugbank ID BE0003740
PharmGKB ID PA31471
Target gene [NCOA2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1002242 chr8 146 34 128 308 View
1002282 chr8 147 34 119 300 View
1002283 chr8 147 34 119 300 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of NCOA2 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
NCOA2 expression: Low -> High
Lollipop of NCOA2 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of NCOA2 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of NCOA2 expression and immune infiltrating cell level correlation result in HBV+ samples
NCOA2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).