HIV Target gene Detail Information

> NCOA1 Gene Search Result

Gene Information

Gene Name	NCOA1
Gene ID	8648
Gene Full Name	nuclear receptor coactivator 1
Gene Alias	SRC1; KAT13A; RIP160; F-SRC-1; bHLHe42; bHLHe74
Transcripts	ENSG00000084676
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;Plasma membrane;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Transcription factors
Uniport_ID	Q15788
HGNC ID	HGNC:7668
VEGA ID	OTTHUMG00000125523
OMIM ID	602691
String ID	9606.ENSP00000385216
Drugbank ID	BE0003728
PharmGKB ID	PA31470

Target gene [NCOA1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001449	chr2	152	2	9	163	View
4004724	chr2	9	31		40	View
4006768	chr2	20	3		23	View
4012101	chr2	2	2	1	5	View
4014735	chr2	2			2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of NCOA1 expression and immune infiltrating cell level correlation result in HIV+ samples
NCOA1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of NCOA1 expression and immune infiltrating cell level correlation result in HIV+ samples
NCOA1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).