HBV Target gene Detail Information

> MYLK Gene Search Result

Gene Information

Gene Name	MYLK
Gene ID	4638
Gene Full Name	myosin light chain kinase
Gene Alias	KRP; AAT7; MLCK; MLCK1; MYLK1; smMLCK; MLCK108; MLCK210; MSTP083
Transcripts	ENSG00000065534
Virus	HBV
Gene Type	protein coding
HPA Location Info	Actin filaments;Plasma membrane;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q15746
HGNC ID	HGNC:7590
VEGA ID	OTTHUMG00000141304
OMIM ID	600922
String ID	9606.ENSP00000353452
Drugbank ID	BE0009446
Drug (Cytoscape Annotation)	Sunitinib Malate;Bosutinib;Ruxolitinib Phosphate
PharmGKB ID	PA31388

Target gene [MYLK] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1000994	chr3	13	860	312	1185	View
1001000	chr3	14	849	310	1173	View
1006863	chr3	6	3	24	33	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of MYLK expression and immune infiltrating cell level correlation result in HBV+ samples
MYLK expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).