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HBV Target gene Detail Information

> MTHFD1 Gene Search Result


Gene Information
Gene Name MTHFD1
Gene ID 4522
Gene Full Name methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
Gene Alias CIMAH; MTHFC; MTHFD
Transcripts ENSG00000100714
Virus HBV
Gene Type protein coding
HPA Location Info Cytosol;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID P11586
HGNC ID HGNC:7432
VEGA ID OTTHUMG00000141309
OMIM ID 172460
String ID 9606.ENSP00000216605
Drugbank ID BE0000617
PharmGKB ID PA31236
Target gene [MTHFD1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1006536 chr14 7 3 27 37 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of MTHFD1 expression and immune infiltrating cell level correlation result in HBV+ samples
MTHFD1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).