HIV Target gene Detail Information

> MPL Gene Search Result

Gene Information

Gene Name	MPL
Gene ID	4352
Gene Full Name	MPL proto-oncogene, thrombopoietin receptor
Gene Alias	MPLV; TPOR; C-MPL; CD110; THCYT2
Transcripts	ENSG00000117400
Virus	HIV
Gene Type	protein coding
HPA Location Info	Plasma membrane;Nuclear membrane;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins
Gene Function	Oncogene
Uniport_ID	P40238
HGNC ID	HGNC:7217
VEGA ID	OTTHUMG00000007429
OMIM ID	159530
String ID	9606.ENSP00000361548
Drugbank ID	BE0003440
PharmGKB ID	PA30923

Target gene [MPL] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000653	chr1	5	230	96	331	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of MPL expression and immune infiltrating cell level correlation result in HIV+ samples
MPL expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of MPL expression and immune infiltrating cell level correlation result in HIV+ samples
MPL expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).