HTLV1 Target gene Detail Information

> MOCOS Gene Search Result

Gene Information

Gene Name	MOCOS
Gene ID	55034
Gene Full Name	molybdenum cofactor sulfurase
Gene Alias	MCS; MOS; HMCS
Transcripts	ENSG00000075643
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Mitochondria;Cytosol;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q96EN8
HGNC ID	HGNC:18234
VEGA ID	OTTHUMG00000132590
OMIM ID	613274
String ID	9606.ENSP00000261326
Drugbank ID	BE0002167
PharmGKB ID	PA134964534

Target gene [MOCOS] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6005199	chr18	28	65		93	View
6015979	chr18	13			13	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of MOCOS expression and immune infiltrating cell level correlation result in HTLV1+ samples
MOCOS expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of MOCOS expression and immune infiltrating cell level correlation result in HTLV1+ samples
MOCOS expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of MOCOS expression and immune infiltrating cell level correlation result in HTLV1+ samples
MOCOS expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).