HPV Target gene Detail Information

> MN1 Gene Search Result

Gene Information

Gene Name	MN1
Gene ID	4330
Gene Full Name	MN1 proto-oncogene, transcriptional regulator
Gene Alias	MGCR; MGCR1; MGCR1-PEN; dJ353E16.2
Transcripts	ENSG00000169184
Virus	HPV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Predicted intracellular proteins
Gene Function	Oncogene
Uniport_ID	Q10571
HGNC ID	HGNC:7180
VEGA ID	OTTHUMG00000150975
OMIM ID	156100
String ID	9606.ENSP00000304956
PharmGKB ID	PA30893

Target gene [MN1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5000291	chr15	304	10	39	353	View
5000755	chr15	84	6		90	View
5201409	chr15	1	1		2	View
5404353	chr22	169	4		173	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE140662 (GEO)	Condyloma Acuminatum	8	Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO)	Head and neck squamous cell carcinoma	270	Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE55546 (GEO)	Oropharyngeal squamous cell carcinoma	16	Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO)	Oropharyngeal squamous cell carcinoma	23	Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO)	Oropharyngeal squamous cell carcinoma	36	Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE51993 (GEO)	Cervical intraepithelial neoplasia	24	Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662
HeatMap of cell type fractions in all samples	Lollipop of MN1 expression and immune infiltrating cell level correlation result in HPV+ samples
MN1 expression: Low -> High

> Dataset: GSE65858
HeatMap of cell type fractions in all samples	Lollipop of MN1 expression and immune infiltrating cell level correlation result in HPV+ samples
MN1 expression: Low -> High

> Dataset: GSE55546
HeatMap of cell type fractions in all samples	Lollipop of MN1 expression and immune infiltrating cell level correlation result in HPV+ samples
MN1 expression: Low -> High

> Dataset: GSE55544
HeatMap of cell type fractions in all samples	Lollipop of MN1 expression and immune infiltrating cell level correlation result in HPV+ samples
MN1 expression: Low -> High

> Dataset: GSE55542
HeatMap of cell type fractions in all samples	Lollipop of MN1 expression and immune infiltrating cell level correlation result in HPV+ samples
MN1 expression: Low -> High

> Dataset: GSE51993
HeatMap of cell type fractions in all samples	Lollipop of MN1 expression and immune infiltrating cell level correlation result in HPV+ samples
MN1 expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of MN1 expression and immune infiltrating cell level correlation result in HPV+ samples
MN1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE140662