HIV Target gene Detail Information

> MMP25 Gene Search Result

Gene Information

Gene Name	MMP25
Gene ID	64386
Gene Full Name	matrix metallopeptidase 25
Gene Alias	MMP20; MMPL1; MMP-25; MMP20A; MT6MMP; MTMMP6; MT-MMP6; MT6-MMP; MT-MMP 6
Transcripts	ENSG00000008516
Virus	HIV
Gene Type	protein coding
HPA Location Info	Plasma membrane;Predicted to be secreted;
HPA Protein Class Info	Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID	Q9NPA2
HGNC ID	HGNC:14246
VEGA ID	OTTHUMG00000177475
OMIM ID	608482
String ID	9606.ENSP00000337816
Drugbank ID	BE0009797; BE0009742
PharmGKB ID	PA30882

Target gene [MMP25] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4006679	chr16	8	13	2	23	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of MMP25 expression and immune infiltrating cell level correlation result in HIV+ samples
MMP25 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of MMP25 expression and immune infiltrating cell level correlation result in HIV+ samples
MMP25 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).