HPV Target gene Detail Information

> MMP12 Gene Search Result

Gene Information

Gene Name	MMP12
Gene ID	4321
Gene Full Name	matrix metallopeptidase 12
Gene Alias	ME; HME; MME; MMP-12
Transcripts	ENSG00000262406
Virus	HPV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Cancer-related genes, Enzymes, FDA approved drug targets, Predicted secreted proteins
Gene Function	Oncogene
Uniport_ID	P39900
HGNC ID	HGNC:7158
VEGA ID	OTTHUMG00000165848
OMIM ID	601046
String ID	9606.ENSP00000458585
Drugbank ID	BE0001198
PharmGKB ID	PA30870

Target gene [MMP12] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5300374	chr11	1			1	View
5404917	chr11	31	3	2	36	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE40774 (GEO)	Head and neck squamous cell carcinoma	134	Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE138080 (GEO)	Cervical intraepithelial neoplasia	25	Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE40774
HeatMap of cell type fractions in all samples	Lollipop of MMP12 expression and immune infiltrating cell level correlation result in HPV+ samples
MMP12 expression: Low -> High

> Dataset: GSE138080
HeatMap of cell type fractions in all samples	Lollipop of MMP12 expression and immune infiltrating cell level correlation result in HPV+ samples
MMP12 expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of MMP12 expression and immune infiltrating cell level correlation result in HPV+ samples
MMP12 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).