HTLV1 Target gene Detail Information

> MLX Gene Search Result

Gene Information

Gene Name	MLX
Gene ID	6945
Gene Full Name	MLX, MAX dimerization protein
Gene Alias	TF4; MAD7; MXD7; TCFL4; bHLHd13
Transcripts	ENSG00000108788
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;Nuclear membrane;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins, Transcription factors
Uniport_ID	Q9UH92
HGNC ID	HGNC:11645
VEGA ID	OTTHUMG00000180246
OMIM ID	602976
String ID	9606.ENSP00000246912
PharmGKB ID	PA36397

Target gene [MLX] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6000188	chr17	2650	257	286	3193	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of MLX expression and immune infiltrating cell level correlation result in HTLV1+ samples
MLX expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of MLX expression and immune infiltrating cell level correlation result in HTLV1+ samples
MLX expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of MLX expression and immune infiltrating cell level correlation result in HTLV1+ samples
MLX expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).