HIV Target gene Detail Information

> MLLT10 Gene Search Result

Gene Information

Gene Name	MLLT10
Gene ID	8028
Gene Full Name	MLLT10, histone lysine methyltransferase DOT1L cofactor
Gene Alias	AF10
Transcripts	ENSG00000078403
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	P55197
HGNC ID	HGNC:16063
VEGA ID	OTTHUMG00000017799
OMIM ID	602409
String ID	9606.ENSP00000307411
PharmGKB ID	PA30849

Target gene [MLLT10] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4006322	chr10	11	14		25	View
4011350	chr10	4	3		7	View
4012189	chr10	5			5	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of MLLT10 expression and immune infiltrating cell level correlation result in HIV+ samples
MLLT10 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of MLLT10 expression and immune infiltrating cell level correlation result in HIV+ samples
MLLT10 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).