HIV Target gene Detail Information

> MLKL Gene Search Result

Gene Information

Gene Name	MLKL
Gene ID	197259
Gene Full Name	mixed lineage kinase domain like pseudokinase
Gene Alias	hMLKL
Transcripts	ENSG00000168404
Virus	HIV
Gene Type	protein coding
HPA Location Info	Plasma membrane;Cell Junctions;Cytosol;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins, Transporters
Uniport_ID	Q8NB16
HGNC ID	HGNC:26617
VEGA ID	OTTHUMG00000177356
OMIM ID	615153
String ID	9606.ENSP00000308351
PharmGKB ID	PA142671349

Target gene [MLKL] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004717	chr16	38		2	40	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of MLKL expression and immune infiltrating cell level correlation result in HIV+ samples
MLKL expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of MLKL expression and immune infiltrating cell level correlation result in HIV+ samples
MLKL expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).