HIV Target gene Detail Information

> MLH3 Gene Search Result

Gene Information

Gene Name	MLH3
Gene ID	27030
Gene Full Name	mutL homolog 3
Gene Alias	HNPCC7
Transcripts	ENSG00000119684
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Disease related genes, Plasma proteins, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q9UHC1
HGNC ID	HGNC:7128
VEGA ID	OTTHUMG00000171766
OMIM ID	604395
String ID	9606.ENSP00000348020
PharmGKB ID	PA30845

Target gene [MLH3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4009530	chr14	8	3		11	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of MLH3 expression and immune infiltrating cell level correlation result in HIV+ samples
MLH3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).