HTLV1 Target gene Detail Information

> MFSD8 Gene Search Result

Gene Information

Gene Name	MFSD8
Gene ID	256471
Gene Full Name	major facilitator superfamily domain containing 8
Gene Alias	CCMD; CLN7
Transcripts	ENSG00000164073
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Vesicles;Nucleoplasm;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Uniport_ID	Q8NHS3
HGNC ID	HGNC:28486
VEGA ID	OTTHUMG00000133303
OMIM ID	611124
String ID	9606.ENSP00000296468
PharmGKB ID	PA162395842

Target gene [MFSD8] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6004677	chr4	95	13		108	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of MFSD8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
MFSD8 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of MFSD8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
MFSD8 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of MFSD8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
MFSD8 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).