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HBV Target gene Detail Information

> METTL4 Gene Search Result


Gene Information
Gene Name METTL4
Gene ID 64863
Gene Full Name methyltransferase like 4
Gene Alias HsT661
Transcripts ENSG00000101574
Virus HBV
Gene Type protein coding
HPA Location Info Mitochondria;
HPA Protein Class Info Predicted intracellular proteins
Uniport_ID Q8N3J2
HGNC ID HGNC:24726
VEGA ID OTTHUMG00000131482
String ID 9606.ENSP00000458290
PharmGKB ID PA134916468
Target gene [METTL4] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1000759 chr18 7 687 805 1499 View
1005012 chr18 11 16 37 64 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of METTL4 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
METTL4 expression: Low -> High
Lollipop of METTL4 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of METTL4 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of METTL4 expression and immune infiltrating cell level correlation result in HBV+ samples
METTL4 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).