HTLV1 Target gene Detail Information

> MEGF6 Gene Search Result

Gene Information

Gene Name	MEGF6
Gene ID	1953
Gene Full Name	multiple EGF like domains 6
Gene Alias	EGFL3
Transcripts	ENSG00000162591
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Microtubules;Cytokinetic bridge;Predicted to be secreted;
HPA Protein Class Info	Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID	O75095
HGNC ID	HGNC:3232
VEGA ID	OTTHUMG00000000611
OMIM ID	604266
String ID	9606.ENSP00000348982
PharmGKB ID	PA27665

Target gene [MEGF6] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6007637	chr1	51	2		53	View
6013521	chr1	4	6	9	19	View
6020039	chr1	5	2		7	View
6020114	chr1	5	2		7	View
6020291	chr1	5	2		7	View
6020292	chr1	5	2		7	View
6022469	chr1	4	1		5	View
6023728	chr1	4			4	View
6025006	chr1	3			3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of MEGF6 expression and immune infiltrating cell level correlation result in HTLV1+ samples
MEGF6 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).