HIV Target gene Detail Information

> MED8 Gene Search Result

Gene Information

Gene Name	MED8
Gene ID	112950
Gene Full Name	mediator complex subunit 8
Gene Alias	ARC32
Transcripts	ENSG00000159479
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Golgi apparatus;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q96G25
HGNC ID	HGNC:19971
VEGA ID	OTTHUMG00000007421
OMIM ID	607956
String ID	9606.ENSP00000290663
PharmGKB ID	PA134893073

Target gene [MED8] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002289	chr1	94	6	1	101	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of MED8 expression and immune infiltrating cell level correlation result in HIV+ samples
MED8 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of MED8 expression and immune infiltrating cell level correlation result in HIV+ samples
MED8 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).