HBV Target gene Detail Information

> MECOM Gene Search Result

Gene Information

Gene Name	MECOM
Gene ID	2122
Gene Full Name	MDS1 and EVI1 complex locus
Gene Alias	EVI1; MDS1; KMT8E; PRDM3; RUSAT2; MDS1-EVI1; AML1-EVI-1
Transcripts	ENSG00000085276
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nuclear speckles;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors
Gene Function	Oncogene
Uniport_ID	Q03112
HGNC ID	HGNC:3498
VEGA ID	OTTHUMG00000158596
OMIM ID	165215
String ID	9606.ENSP00000264674
PharmGKB ID	PA27912

Target gene [MECOM] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1005511	chr3	3	50		53	View
1005512	chr3	3	50		53	View
1006066	chr3	8	20	16	44	View
1016026	chr3		2		2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of MECOM expression and immune infiltrating cell level correlation result in HBV+ samples
MECOM expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).