HBV Target gene Detail Information

> ME1 Gene Search Result

Gene Information

Gene Name	ME1
Gene ID	4199
Gene Full Name	malic enzyme 1
Gene Alias	MES; HUMNDME
Transcripts	ENSG00000065833
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Plasma membrane;Cytosol;
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P48163
HGNC ID	HGNC:6983
VEGA ID	OTTHUMG00000015111
OMIM ID	154250
String ID	9606.ENSP00000358719
Drugbank ID	BE0000604
PharmGKB ID	PA30723

Target gene [ME1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1003468	chr6	114	17		131	View
1006146	chr20	35	5	2	42	View
1006572	chr20	33	2	1	36	View
1017611	chr6				0	View
1018280	chr6				0	View
1018281	chr6				0	View
1401384	chr20	35	5	2	42	View
1401385	chr20	33	2	1	36	View
1403921	chr6				0	View
1403922	chr6	114	17		131	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of ME1 expression and immune infiltrating cell level correlation result in HBV+ samples
ME1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).