HIV Target gene Detail Information

> MDH2 Gene Search Result

Gene Information

Gene Name	MDH2
Gene ID	4191
Gene Full Name	malate dehydrogenase 2
Gene Alias	MDH; MOR1; M-MDH; EIEE51; MGC:3559
Transcripts	ENSG00000146701
Virus	HIV
Gene Type	protein coding
HPA Location Info	Mitochondria;
HPA Protein Class Info	Citric acid cycle related proteins, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P40926
HGNC ID	HGNC:6971
VEGA ID	OTTHUMG00000023827
OMIM ID	154100
String ID	9606.ENSP00000327070
Drugbank ID	BE0000780
PharmGKB ID	PA30716

Target gene [MDH2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003360	chr7	53	10		63	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of MDH2 expression and immune infiltrating cell level correlation result in HIV+ samples
MDH2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of MDH2 expression and immune infiltrating cell level correlation result in HIV+ samples
MDH2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).