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HPV Target gene Detail Information

> MDH1 Gene Search Result


Gene Information
Gene Name MDH1
Gene ID 4190
Gene Full Name malate dehydrogenase 1
Gene Alias MDHA; MOR2; MDH-s; HEL-S-32; MGC:1375
Transcripts ENSG00000014641
Virus HPV
Gene Type protein coding
HPA Location Info Centrosome;Cytosol;
HPA Protein Class Info Cancer-related genes, Citric acid cycle related proteins, Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID P40925
HGNC ID HGNC:6970
VEGA ID OTTHUMG00000129512
OMIM ID 154200
String ID 9606.ENSP00000438144
Drugbank ID BE0000589
PharmGKB ID PA30714
Target gene [MDH1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5300123 chr2 12 5 17 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE40774 (GEO) Head and neck squamous cell carcinoma 134 Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE138080 (GEO) Cervical intraepithelial neoplasia 25 Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE40774

HeatMap of cell type fractions in all samples Lollipop of MDH1 expression and immune infiltrating cell level correlation result in HPV+ samples
MDH1 expression: Low -> High

> Dataset: GSE138080

HeatMap of cell type fractions in all samples Lollipop of MDH1 expression and immune infiltrating cell level correlation result in HPV+ samples
MDH1 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of MDH1 expression and immune infiltrating cell level correlation result in HPV+ samples
MDH1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).