HTLV1 Target gene Detail Information

> MCFD2 Gene Search Result

Gene Information

Gene Name	MCFD2
Gene ID	90411
Gene Full Name	multiple coagulation factor deficiency 2
Gene Alias	F5F8D; SDNSF; F5F8D2; LMAN1IP
Transcripts	ENSG00000180398
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Disease related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q8NI22
HGNC ID	HGNC:18451
VEGA ID	OTTHUMG00000153100
OMIM ID	607788
String ID	9606.ENSP00000386651
Drugbank ID	BE0002120
PharmGKB ID	PA134925788

Target gene [MCFD2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6002758	chr2	146	49	16	211	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of MCFD2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
MCFD2 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of MCFD2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
MCFD2 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of MCFD2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
MCFD2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).