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HTLV1 Target gene Detail Information

> MCF2 Gene Search Result


Gene Information
Gene Name MCF2
Gene ID 4168
Gene Full Name MCF.2 cell line derived transforming sequence
Gene Alias DBL; ARHGEF21
Transcripts ENSG00000101977
Virus HTLV1
Gene Type protein coding
HPA Location Info
HPA Protein Class Info Plasma proteins, Predicted intracellular proteins
Gene Function Oncogene
Uniport_ID P10911
HGNC ID HGNC:6940
VEGA ID OTTHUMG00000022537
OMIM ID 311030
String ID 9606.ENSP00000430276
PharmGKB ID PA30684
Target gene [MCF2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6005155 chrX 82 12 94 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of MCF2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
MCF2 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of MCF2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
MCF2 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of MCF2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
MCF2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).