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HBV Target gene Detail Information

> MCC Gene Search Result


Gene Information
Gene Name MCC
Gene ID 4163
Gene Full Name MCC, WNT signaling pathway regulator
Gene Alias MCC1
Transcripts ENSG00000171444
Virus HBV
Gene Type protein coding
HPA Location Info Cytosol;Nucleoplasm;Cytoplasmic bodies;
HPA Protein Class Info Predicted intracellular proteins
Gene Function Suppressor gene & Oncogene
Uniport_ID P23508
HGNC ID HGNC:6935
VEGA ID OTTHUMG00000128804
OMIM ID 159350
String ID 9606.ENSP00000386227
PharmGKB ID PA30679
Target gene [MCC] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1005978 chr5 45 45 View
1007458 chr5 25 1 1 27 View
1007506 chr5 21 6 27 View
1012306 chr5 6 1 7 View
1404313 chr5 3 3 6 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of MCC expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
MCC expression: Low -> High
Lollipop of MCC expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of MCC expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of MCC expression and immune infiltrating cell level correlation result in HBV+ samples
MCC expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).