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HPV Target gene Detail Information

> MC4R Gene Search Result


Gene Information
Gene Name MC4R
Gene ID 4160
Gene Full Name melanocortin 4 receptor
Transcripts ENSG00000166603
Virus HPV
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins, Transporters
Uniport_ID P32245
HGNC ID HGNC:6932
VEGA ID OTTHUMG00000132766
OMIM ID 155541
String ID 9606.ENSP00000299766
Drugbank ID BE0009604; BE0009682
PharmGKB ID PA30676
Target gene [MC4R] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5200491 chr18 2 2 View
5201214 chr18 0 View
5403453 chr18 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE140662 (GEO) Condyloma Acuminatum 8 Condyloma acuminata (HPV+)(5), Skin(3)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662

HeatMap of cell type fractions in all samples Lollipop of MC4R expression and immune infiltrating cell level correlation result in HPV+ samples
MC4R expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of MC4R expression and immune infiltrating cell level correlation result in HPV+ samples
MC4R expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of MC4R expression and immune infiltrating cell level correlation result in HPV+ samples
MC4R expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of MC4R expression and immune infiltrating cell level correlation result in HPV+ samples
MC4R expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of MC4R expression and immune infiltrating cell level correlation result in HPV+ samples
MC4R expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of MC4R expression and immune infiltrating cell level correlation result in HPV+ samples
MC4R expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).