HTLV1 Target gene Detail Information

> MBP Gene Search Result

Gene Information

Gene Name	MBP
Gene ID	4155
Gene Full Name	myelin basic protein
Transcripts	ENSG00000197971
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Plasma membrane;
HPA Protein Class Info	Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P02686
HGNC ID	HGNC:6925
VEGA ID	OTTHUMG00000132874
OMIM ID	159430
String ID	9606.ENSP00000380958
PharmGKB ID	PA30667

Target gene [MBP] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6002568	chr18	227	2		229	View
6014901	chr18	14	1		15	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of MBP expression and immune infiltrating cell level correlation result in HTLV1+ samples
MBP expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of MBP expression and immune infiltrating cell level correlation result in HTLV1+ samples
MBP expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of MBP expression and immune infiltrating cell level correlation result in HTLV1+ samples
MBP expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).