HTLV1 Target gene Detail Information

> MASTL Gene Search Result

Gene Information

Gene Name	MASTL
Gene ID	84930
Gene Full Name	microtubule associated serine/threonine kinase like
Gene Alias	GW; GWL; THC2; MAST-L; GREATWALL
Transcripts	ENSG00000120539
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q96GX5
HGNC ID	HGNC:19042
VEGA ID	OTTHUMG00000017855
OMIM ID	608221
String ID	9606.ENSP00000365107
PharmGKB ID	PA134943781

Target gene [MASTL] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6010456	chr10	31			31	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of MASTL expression and immune infiltrating cell level correlation result in HTLV1+ samples
MASTL expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of MASTL expression and immune infiltrating cell level correlation result in HTLV1+ samples
MASTL expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of MASTL expression and immune infiltrating cell level correlation result in HTLV1+ samples
MASTL expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).