HIV Target gene Detail Information

> MARK3 Gene Search Result

Gene Information

Gene Name	MARK3
Gene ID	4140
Gene Full Name	microtubule affinity regulating kinase 3
Gene Alias	KP78; CTAK1; PAR1A; Par-1a
Transcripts	ENSG00000075413
Virus	HIV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	P27448
HGNC ID	HGNC:6897
VEGA ID	OTTHUMG00000171789
OMIM ID	602678
String ID	9606.ENSP00000411397
Drugbank ID	BE0009435
PharmGKB ID	PA30640

Target gene [MARK3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000821	chr14	209	59	4	272	View
4001534	chr14	73	72	8	153	View
4001773	chr14	118	12	3	133	View
4002980	chr14	71	1	1	73	View
4003792	chr14	38	14	2	54	View
4006114	chr14	20	6	1	27	View
4006264	chr14	23	2	1	26	View
4007043	chr14	8	13		21	View
4007842	chr14	14	3		17	View
4008930	chr14	5	3	5	13	View
4012399	chr14	5			5	View
4015616	chr14	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of MARK3 expression and immune infiltrating cell level correlation result in HIV+ samples
MARK3 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of MARK3 expression and immune infiltrating cell level correlation result in HIV+ samples
MARK3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).