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HBV Target gene Detail Information

> MAPKAPK2 Gene Search Result


Gene Information
Gene Name MAPKAPK2
Gene ID 9261
Gene Full Name mitogen-activated protein kinase-activated protein kinase 2
Gene Alias MK2; MK-2; MAPKAP-K2
Transcripts ENSG00000162889
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoplasm;Centrosome;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Enzymes, Predicted membrane proteins
Uniport_ID P49137
HGNC ID HGNC:6887
VEGA ID OTTHUMG00000036342
OMIM ID 602006
String ID 9606.ENSP00000356070
Drugbank ID BE0001373
PharmGKB ID PA30631
Target gene [MAPKAPK2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1001870 chr1 42 286 115 443 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of MAPKAPK2 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
MAPKAPK2 expression: Low -> High
Lollipop of MAPKAPK2 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of MAPKAPK2 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of MAPKAPK2 expression and immune infiltrating cell level correlation result in HBV+ samples
MAPKAPK2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).