HTLV1 Target gene Detail Information

> MAPK9 Gene Search Result

Gene Information

Gene Name	MAPK9
Gene ID	5601
Gene Full Name	mitogen-activated protein kinase 9
Gene Alias	JNK2; SAPK; p54a; JNK2A; JNK2B; PRKM9; JNK-55; SAPK1a; JNK2BETA; p54aSAPK; JNK2ALPHA
Transcripts	ENSG00000050748
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Enzymes, Predicted intracellular proteins, RAS pathway related proteins
Gene Function	Suppressor gene
Uniport_ID	P45984
HGNC ID	HGNC:6886
VEGA ID	OTTHUMG00000130934
OMIM ID	602896
String ID	9606.ENSP00000394560
Drugbank ID	BE0003772; BE0009865; BE0009853
PharmGKB ID	PA30630

Target gene [MAPK9] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6008841	chr5	39	3		42	View
6014501	chr5	7	9		16	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of MAPK9 expression and immune infiltrating cell level correlation result in HTLV1+ samples
MAPK9 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of MAPK9 expression and immune infiltrating cell level correlation result in HTLV1+ samples
MAPK9 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of MAPK9 expression and immune infiltrating cell level correlation result in HTLV1+ samples
MAPK9 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).