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HBV Target gene Detail Information

> MAP4K4 Gene Search Result


Gene Information
Gene Name MAP4K4
Gene ID 9448
Gene Full Name mitogen-activated protein kinase kinase kinase kinase 4
Gene Alias HGK; NIK; MEKKK4; FLH21957; HEL-S-31
Transcripts ENSG00000071054
Virus HBV
Gene Type protein coding
HPA Location Info
HPA Protein Class Info Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID O95819
HGNC ID HGNC:6866
VEGA ID OTTHUMG00000155394
OMIM ID 604666
String ID 9606.ENSP00000343658
Drugbank ID BE0009427
Drug (Cytoscape Annotation) Bosutinib;Sunitinib Malate;Axitinib
PharmGKB ID PA30612
Target gene [MAP4K4] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1002512 chr2 98 112 48 258 View
1402853 chr2 98 112 48 258 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of MAP4K4 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
MAP4K4 expression: Low -> High
Lollipop of MAP4K4 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of MAP4K4 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of MAP4K4 expression and immune infiltrating cell level correlation result in HBV+ samples
MAP4K4 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).