HIV Target gene Detail Information

> MAP4K3 Gene Search Result

Gene Information

Gene Name	MAP4K3
Gene ID	8491
Gene Full Name	mitogen-activated protein kinase kinase kinase kinase 3
Gene Alias	GLK; MEKKK3; MEKKK 3; MAPKKKK3; RAB8IPL1
Transcripts	ENSG00000011566
Virus	HIV
Gene Type	protein coding
HPA Location Info	Centriolar satellite;Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q8IVH8
HGNC ID	HGNC:6865
VEGA ID	OTTHUMG00000102127
OMIM ID	604921
String ID	9606.ENSP00000263881
Drugbank ID	BE0009426
PharmGKB ID	PA30611

Target gene [MAP4K3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003866	chr2	31	18	4	53	View
4004346	chr2	13	22	11	46	View
4008237	chr2	9	7		16	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of MAP4K3 expression and immune infiltrating cell level correlation result in HIV+ samples
MAP4K3 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of MAP4K3 expression and immune infiltrating cell level correlation result in HIV+ samples
MAP4K3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).