HIV Target gene Detail Information

> MAP3K14 Gene Search Result

Gene Information

Gene Name	MAP3K14
Gene ID	9020
Gene Full Name	mitogen-activated protein kinase kinase kinase 14
Gene Alias	HS; NIK; HSNIK; FTDCR1B
Transcripts	ENSG00000282637
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Vesicles;Nucleoli fibrillar center;Nucleoplasm;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Uniport_ID	Q99558
HGNC ID	HGNC:6853
VEGA ID	OTTHUMG00000190406
OMIM ID	604655
String ID	9606.ENSP00000482657
PharmGKB ID	PA30597

Target gene [MAP3K14] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001842	chr17	42	26	59	127	View
4003077	chr17	16	53	1	70	View
4003904	chr17	50	1	1	52	View
4005095	chr17	25	10	1	36	View
4005312	chr17	23	9	2	34	View
4006992	chr17	21			21	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of MAP3K14 expression and immune infiltrating cell level correlation result in HIV+ samples
MAP3K14 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of MAP3K14 expression and immune infiltrating cell level correlation result in HIV+ samples
MAP3K14 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).