HIV Target gene Detail Information

> MAP3K1 Gene Search Result

Gene Information

Gene Name	MAP3K1
Gene ID	4214
Gene Full Name	mitogen-activated protein kinase kinase kinase 1
Gene Alias	MEKK; MEKK1; SRXY6; MEKK 1; MAPKKK1
Transcripts	ENSG00000095015
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins
Uniport_ID	Q13233
HGNC ID	HGNC:6848
VEGA ID	OTTHUMG00000059486
OMIM ID	600982
String ID	9606.ENSP00000382423
Drugbank ID	BE0003430
PharmGKB ID	PA30592

Target gene [MAP3K1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003627	chr5	25	32		57	View
4010222	chr5	7	2		9	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of MAP3K1 expression and immune infiltrating cell level correlation result in HIV+ samples
MAP3K1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of MAP3K1 expression and immune infiltrating cell level correlation result in HIV+ samples
MAP3K1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).