Home
Virus
Gene
Disease
Dataset
Download
Help
 
HBV Target gene Detail Information

> MAP2K7 Gene Search Result


Gene Information
Gene Name MAP2K7
Gene ID 5609
Gene Full Name mitogen-activated protein kinase kinase 7
Gene Alias MEK; MKK7; JNKK2; MEK 7; MAPKK7; PRKMK7; SAPKK4; SAPKK-4
Transcripts ENSG00000076984
Virus HBV
Gene Type protein coding
HPA Location Info Cytosol;Plasma membrane;Golgi apparatus;
HPA Protein Class Info Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID O14733
HGNC ID HGNC:6847
VEGA ID OTTHUMG00000137368
OMIM ID 603014
String ID 9606.ENSP00000381070
PharmGKB ID PA284
FDA Approved Drug Cobimetinib;Trametinib
Target gene [MAP2K7] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1001578 chr19 599 6 605 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of MAP2K7 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
MAP2K7 expression: Low -> High
Lollipop of MAP2K7 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of MAP2K7 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of MAP2K7 expression and immune infiltrating cell level correlation result in HBV+ samples
MAP2K7 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).