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HBV Target gene Detail Information

> MAP2K4 Gene Search Result


Gene Information
Gene Name MAP2K4
Gene ID 6416
Gene Full Name mitogen-activated protein kinase kinase 4
Gene Alias JNKK; MEK4; MKK4; SEK1; SKK1; JNKK1; SERK1; MAPKK4; PRKMK4; SAPKK1; SAPKK-1
Transcripts ENSG00000065559
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoplasm;Cell Junctions;
HPA Protein Class Info Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
Gene Function Suppressor gene
Uniport_ID P45985
HGNC ID HGNC:6844
VEGA ID OTTHUMG00000178267
OMIM ID 601335
String ID 9606.ENSP00000410402
Drug (Cytoscape Annotation) Sunitinib Malate;Pazopanib Hydrochloride
PharmGKB ID PA30589
Target gene [MAP2K4] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1015792 chr17 1 1 2 View
1017047 chr17 1 1 View
1017048 chr17 1 1 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of MAP2K4 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
MAP2K4 expression: Low -> High
Lollipop of MAP2K4 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of MAP2K4 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of MAP2K4 expression and immune infiltrating cell level correlation result in HBV+ samples
MAP2K4 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).