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HBV Target gene Detail Information

> MAP2K3 Gene Search Result


Gene Information
Gene Name MAP2K3
Gene ID 5606
Gene Full Name mitogen-activated protein kinase kinase 3
Gene Alias MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2
Transcripts ENSG00000034152
Virus HBV
Gene Type protein coding
HPA Location Info Cytosol;Nucleoplasm;
HPA Protein Class Info Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID P46734
HGNC ID HGNC:6843
VEGA ID OTTHUMG00000134322
OMIM ID 602315
String ID 9606.ENSP00000345083
Drugbank ID BE0009413
Drug (Cytoscape Annotation) Ruxolitinib Phosphate
PharmGKB ID PA30588
Target gene [MAP2K3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1004555 chr17 75 1 1 77 View
1012378 chr17 7 7 View
1013071 chr17 5 5 View
1400851 chr17 5 5 View
1403575 chr17 75 1 1 77 View
1404992 chr17 2 3 5 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of MAP2K3 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
MAP2K3 expression: Low -> High
Lollipop of MAP2K3 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of MAP2K3 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of MAP2K3 expression and immune infiltrating cell level correlation result in HBV+ samples
MAP2K3 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).