HIV Target gene Detail Information

> MAP2K2 Gene Search Result

Gene Information

Gene Name	MAP2K2
Gene ID	5605
Gene Full Name	mitogen-activated protein kinase kinase 2
Gene Alias	CFC4; MEK2; MKK2; MAPKK2; PRKMK2
Transcripts	ENSG00000126934
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, RAS pathway related proteins
Uniport_ID	P36507
HGNC ID	HGNC:6842
VEGA ID	OTTHUMG00000134286
OMIM ID	601263
String ID	9606.ENSP00000262948
Drugbank ID	BE0004744
PharmGKB ID	PA30587

Target gene [MAP2K2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002749	chr19	69	5	7	81	View
4010853	chr19	7	1		8	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of MAP2K2 expression and immune infiltrating cell level correlation result in HIV+ samples
MAP2K2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of MAP2K2 expression and immune infiltrating cell level correlation result in HIV+ samples
MAP2K2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).