HIV Target gene Detail Information

> MALT1 Gene Search Result

Gene Information

Gene Name	MALT1
Gene ID	10892
Gene Full Name	MALT1 paracaspase
Gene Alias	MLT; MLT1; IMD12; PCASP1
Transcripts	ENSG00000172175
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoli fibrillar center;Cytosol;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Gene Function	Oncogene
Uniport_ID	Q9UDY8
HGNC ID	HGNC:6819
VEGA ID	OTTHUMG00000132761
OMIM ID	604860
String ID	9606.ENSP00000319279
PharmGKB ID	PA30568

Target gene [MALT1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4006825	chr18	19	3		22	View
4012928	chr18		4		4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of MALT1 expression and immune infiltrating cell level correlation result in HIV+ samples
MALT1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of MALT1 expression and immune infiltrating cell level correlation result in HIV+ samples
MALT1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).