HIV Target gene Detail Information

> MADD Gene Search Result

Gene Information

Gene Name	MADD
Gene ID	8567
Gene Full Name	MAP kinase activating death domain
Gene Alias	DENN; IG20; RAB3GEP
Transcripts	ENSG00000110514
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Plasma membrane;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted intracellular proteins, Predicted membrane proteins
Gene Function	Suppressor gene
Uniport_ID	Q8WXG6
HGNC ID	HGNC:6766
VEGA ID	OTTHUMG00000150350
OMIM ID	603584
String ID	9606.ENSP00000310933
PharmGKB ID	PA30523

Target gene [MADD] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002985	chr11	45	23	5	73	View
4006355	chr11	21	4		25	View
4016166	chr11				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of MADD expression and immune infiltrating cell level correlation result in HIV+ samples
MADD expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of MADD expression and immune infiltrating cell level correlation result in HIV+ samples
MADD expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).